This dataset contains the results of laser ablation inductively-coupled mass spectrometry (LA-ICP-MS) analysis of deep-sea ferromanganese nodules. The results, provided in a Microsoft Excel spreadsheet, are for nodules collected as part of the Seabed Mining And Resilience To EXperimental impact (SMARTEX) Highlight Topic project funded by the UK Natural Environment Research Council (Grant References NE/T003537/1 and NE/T002883/1) alongside other partner institutions in the project. These high resolution and in-situ analyses were performed as time series LA-ICP-MS line scans across full, or half transects of selected nodules previously imaged by the scanning electron microscope (SEM) and data is displayed for 34 elements. Separate datasets associated with the same project cover porewater geochemistry, the geochemistry and mineralogy of sediment, and physical property analysis of sediment to model the physical and temporal responses of deep-sea sediment to the compression caused by a deep-sea mining vessel. The samples were collected as part of Expedition JC241 2023 in the Ocean Minerals Company (OMCO) test mining site in the Clarion-Clipperton Zone of the Central Pacific Ocean. More information, location and the cruise report are available at www.bodc.ac.uk/resources/inventories/cruise_inventory/report/18136/